Book Chapters


Journal Articles


“A small molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases,” R.C. Coll, A.A.B. Robertson, J.J. Chae, S.C.. Higgins, R. Muñoz-Planillo, M.C.. Inserra, I. Vetter, L.S.. Dungan, B.G.. Monks, A. Stutz, D.E. Croker, M.S. Butler, M. Haneklaus, C.E. Sutton, G. Núñez, E. Latz, D.L. Kastner, K.H.G. Mills, S.L. Masters, K. Schroder, MA Cooper, L.A.J. O’Neill Nature Medicine, 2015, DOI: 10.1038/NM.3806

“Synthesis of norbornane biesther antibiotics via silver-mediated alkylation”, S.M. Hickey, T.D. Ashton, J.M. White, J. Li, R.L. Nation, H.Y. Yu, A.G. Elliott, M.S. Butler, J.X. Huang, M.A. Cooper & F.M. Pfeffer, RSC Advances, ePub 16 March 2015.

“The C. difficile treatment pipeline: challenges in discovery and development of new agents”. A. Jarrad, T. Karoli, M.A. Blaskovich, D. Lyras & M.A. Cooper. J. Med. Chem. DOI: 10.1021/jm5016846 ePub 11 March 2015.

“QCM-based rapid analysis of DNA” F.N. Dultsev, E.A. Kolosovsky, M.A. Cooper, A.A. Lomzov, D.V. Pyshnyi”, Sens. Biosens. Res., 2015 doi:10.1016/j.sbsr.2014.10.004

“α-Conotoxin dendrimers have enhanced potency and selectivity for nicotinic acetylcholine receptors”, J. Wan, J.X. Huang, I. Vetter, M. Mobli, J. Lawson, H.S. Tae, N. Abraham, P. Blessy, M.A. Cooper, D. Adams, R. Lewis & P. Alewood, J. Am Chem Soc, 2015, 137 (9), 3209-3212  DOI: 10.1021/jacs.5b00244

“Evaluation of direct and multi-layer passivation and capture chemistries for nanoparticle-based biosensor applications.” S. KC, A. Ranzoni & M.A. Cooper, Biosensors & Bioelectronics. 2015, 769-774.  DOI: 10.1016/j.bios.2014.09.048

“Affinities and in-plane stress forces between glycopeptide antibiotics and biomimetic bacterial membranes.” S. Bi, A. Ranzoni, J.X. Huang, K. Hansford & M.A. Cooper, Sensing and Bio-Sensing Research, 2015, 24-30.  DOI: 10.1016/j.sbsr.2014.10.003

“A new antibiotic with potent activity against Gram-positive bacteria targets MscL”. I. Iscla, R. Wray, P. Blount, J. Larkins-Ford, A.L. Conery, F.M. Ausubel, S. Ramu, A. Kavanagh, J.X. Huang, M.A. Blaskovich, M.A. Cooper, A. Obregon-Henao, I Orme, E.S. Tjandra, U. Stroeher, M. Brown, C. Macardle, N. van Holst, C.L. Tong, A.D. Slattery, C.T. Gibon, C.L. Raston & R.A. Boulos. J. Antibiotics. 2015, Feb 4 ePub, ahead of print.

“Facile synthesis of mono- and bis-methylated Fmoc-Dap, -Dab and –Orn building blocks”, F. Lindahl, H. Huang, D.P.Fairlie & M.A. Cooper, Chem. Comm. 2015, Advance Article Doi: 10.1039/C4CC09780G

“Drug-drug plasma protein binding interactions of ivacaftor”, E. Schneider, J. Huang, V. Carbone, M. Baker, J. Striessnig, M. Azad, M.A. Cooper, J. Li. J. Molec. Recog., ePub 24 February 2015.



“Surface stress sensors for rapid and ultrasensitive detection of active free drugs in human serum”,  J.W. Ndieyira, N. Kappeler, S. Logan, M.A. Cooper, C. Abell, R.A. McKendry & G. Aeppli, Nature Nanotechnology. 2014, 9, 225 - 232. DOI: 10.10

“Imperfect coordination chemistry facilititates metal ion release in the Psa permease”, R. M. Counago, M.P. Ween, S.L. Begg, M. Bajaj, J. Zuegg, M.L. O’Mara, M.A. Cooper, A.G. McEwan, J.C. Paton, B. Kobe, and C.A. McDevitt, Nature Chem Biol, 2014; 10, 35-41.

“Natural product and natural product derived drugs in clinical trials”. M.S. Butler, A.A.B. Robertson & M.A. Cooper. Natural Product Reports. 2014, 31, 1612 – 1661

“Cell- and biomarker-based assays for predicting nephrotoxicity”. J. Huang, M.A. Blaskovich &  M.A. Cooper. Expert Opinion on Drug Metabolism & Toxicology. 2014, 10 (12) 1621-1635 doi:  10.1517/17425255.2014.967681

“Ramoplanin at bacterial concentrations induces bacterial membrane depolarization in Staphylococcus aureus”, M. Cheng, J.X. Huang, S. Ramu, M.S. Butler and M.A. Cooper, Antimicrob Agents and Chemo. 2014, 58(11) 6819-6827.

“Derivations of ligands for the complement C3a receptor from the C-terminus of C5a”, R. Halai, M.L. Bellows-Petersen, W. Branchett, J. Smadbeck, C.A. Kieslich, D.E. Croker, M.A. Cooper, D. Morikis, T.M. Woodruff, C.A. Floudas & P.A. Monk. European J Pharmacol. 2014, 745, 15 Dec, 176-181.

"Affinities and in-plane stress forces between glycopeptide antibiotics and biomimetic bacterial membranes." S. Bi, A. Ranzoni, J.X Huang, K. Hansford & M.A. Cooper. Biosensors & Bioelectronics. 2015, 24-30. doi:10.1016/j.sbsr.2014.10.003

“Glycopeptide Antibiotics: Back to the Future”, M.S. Butler, K.A. Hansford, M.A. Blaskovich & M.A. Cooper, Journal of Antibiotics 2014, 67, 631-644.

“Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction”,  C.J. Greenhill, G.W. Jones, M.A. Nowell, A.K. Harvey, A.N. Moiden, F.L. Collins, A.C. Bloom, R.C. Coll, A.B. Robertson, M.A. Cooper, M. Rosas, P.R. Taylor, L.A. O’Neill, I.R. Humphreys, A.S. Williams & S.R. Jones. Arthritis Research & Therapy, 2014, 16, 419 - 428. doi:10.1186/s13075-014-0419-y

“An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants” W. Phetsang, M.A. Blaskovich & M.A. Cooper Biorg Med Chem. 2014, 22, 4490-4498. doi.10.1016/j.bmc.2014.05.054

“Pathway-selective antagonism of proteinase activated receptor 2”. J.Y. Suen, A. Cotterell, R.-J. Lohman, J. Lim, A. Han, M.-K. Yau, L. Liu, M.A. Cooper, D.A. Vesey, & D.P. Fairlie.  Brit. J. Pharmacol. 2014, 171 (17), 4112-4124.  doi: 10.1111/bph.12757

“C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and b-arrestin recruitment”, D.E. Croker, R. Halai, G. Kaeslin, E. Wende, B. Fehlhaber, A. Klos, P. Monk & M.A. Cooper. Immunol. Cell Biol. 2014, (92), 631-639.  doi: 10.1038/icb.2014.32

“Natural product libraries: assembly, maintenance and screening”, M.S. Butler, F.R. Fontaine & M.A. Cooper. Planta Medica. 2014, 80, 1161-1170.

“Monoacetylation of carbohydrate diols via trans-esterification with ethyl acetate” X. Lu, B. Becker & M.A. Cooper, Australian Journal of Chemistry. 2014, 67, 679-683

“Anti-cooperative ligand binding and dimerization in the glycopeptide antibiotic dalbavancin”, M. Cheng, Z. Ziora, K. Hansford, M.A. Blaskovich, M.S. Butler & M.A. Cooper. Organic & Biomol. Chem. 2014, 12 (16), 2568-2575.

“In vivo evolution of antimicrobial resistance in a series of Staphylococcus aureus patient isolates: the entire picture or a cautionary tale?” S.J. van Hal, J.A. Steen, B.A. Espedido, S.M.Grimmond, M.A. Cooper, M.T.G. Holden, S.D. Bentley, I.B. Gosbell & S.O. Jensen. Journal of Antimicrobial Chemotherapy. 2014, 69(2): 363-67. doi:10.1093/jac/dkt354.

“Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae”,  T. Velkov, Z. Deris, Z. Zakuan, J.X. Huang, M.A.K. Azad, M.S. Butler, S. Sivanesan, L.M. Kaminskas, Y-D. Dong, B. Bod, M.A. Baker, M.A. Cooper, R.L. Nation & J. Li, Innate Immunity. 2014, 20(4): 350-63. DOI: 10.1177/1753425913493337.



“Fine tuning the disassembly time of thermoresponsive polymer nanoparticles”. Nguyen T.D. Tran, Z. Jia, N.T. Phuoc, M.A.Cooper, M.J. Monteiro. Biomacromol., 2013, 14(10): 3463-471.

"C5a, but not C5a-des Arg induces upregulation of heteromer formation between its complement C5a receptors C5aR and C5L2”, D.E. Croker, R. Halai, D.P. Fairlie, M.A. Cooper. Immunol & Cell Biol., 2013, 91(10): 625-33.

"Neutrophils: a key component of ischemia reperfusion injury”, Z.V. Schofield, T.M. Woodruff, R. Halai, M. C-L Wu, M.A. Cooper. Shock, 2013, 40 (6): 463-70.

“Nanoparticle sample preparation and mass spectrometry for rapid diagnosis of microbial infections” A. Ranzoni, H. Sidjabat and M.A. Cooper. Microbiology Australia, Nov 2013, 34 (4), 170-174.

“Probing the reactivity of o-phthalaldehydic acid/methyl ester: synthesis of N-isoindolinones and 3-arylaminophthalides”. S.K. Mamidyala and M.A. Cooper. Chem. Comm. 2013, 49(75): 8407-409. DOI:10.1039/C3CC43838D

“Antibiotics in the clinical pipeline in 2013”, M.S. Butler, M.A. Blaskovich and M.A. Cooper,
J. Antibiot., 2013,  66(10): 571-91  doi:10.1038/ja.2013.86

“Comparison of surface plasmon resonance, resonant waveguide grating biosensing and ELISA in the evaluation of a Dengue virus immunoassay”. D. Hu, S.R. Fry, J.X. Huang, X. Ding, L. Qiu, Y. Pan, Y. Chen, J. Jin, C. McElnea, J. Buechler, X. Che, & M.A. Cooper. Biosensors, 2013, 3, 297-311. Doi: 10.3390/bios3030297

“A paramagnetic-reporter two-particle system for amplification-free detection of DNA in serum”. D.A.C. Thomson and M.A. Cooper. Biosensors and Bioelectronics. 2013, 50, 499-501.

“The antigenic architecture of the hemagglutinin of influenza H5N1 viruses” T. Velkov, C. Ong, M.A. Baker, H. Kim, J. Li, R.L. Nation, J.X. Huang, M.A. Cooper and S. Rockman. Molecular Immunology, 2013, 56(4): 705-719.

“Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae” by T. Velkov, Z.Z. Deris, J. Huang, M. Azad, C. Dong, B. Boyd, M. Baker, M.A. Cooper, R. Nation, and J. Li. Innate Immunity, E-pub ahead of print 25 July 2013, DOI: 10.1177/1753425913493337

“Molecular characterization of the receptor binding structure-activity relationships of influenza B virus hemagglutinin”, V. Carbone, H. Kim, J.X. Huang, M.A/ Baker, C. Ong, M.A. Cooper, J. Li, S. Rockman, T. Velkov. Acta virologica, 2013, 57(3): 313-52.

“The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes”, R.C. Coll, A.A.B. Robertson, M.S. Butler, M.A. Cooper, L.A.J. O'Neill, Plos One, 6(12): e29539. 2013 doi:10.1371/journal.pone.0029539

"Antibacterial serrulatane diterpenes from the Australian native plant Eremophila microtheca”, E.C. Barnes, A.M. Kavanagh, S. Ramu, M.A. Blaskovich, M. A. Cooper, and R.A. Davis, Phytochemistry, 2013, 93, 162-169.

“Whole Genome Sequence Analysis of the First Australian OXA-48-Producing Outbreak-Associated Klebsiella pneumoniae Isolates: The Resistome and in vivo Evolution”, B. Espedido, J. Steen, H. Ziochos, S. Grimmond, M.A Cooper; I. Gosbell, S. van Hal, S. Jensen. Plos One, 2013, 8 (3) e59920. DOI: 10.1371/journal/pone.0059920.

“Efficient synthesis of anacardic acid analogues and their antibacterial activities”, S.K. Mamidyala, S. Ramu, J.X. Huang, A.B. Robertson, M.A. Cooper, Bioorg Med Chem Lett, 2013, 23 (6): 1667-670. DOI:10.1016/j.bmcl.2013.01.074

“Timed-release polymer nanoparticles”, T.D.T. Nguyen, N.P. Truong, W. Gu, Z. Jia,  M.A. Cooper, M.J. Monteiro, Biomacromolecules. 2013, 14(2), 495-502.

“Vancomycin: Ligand recognition, Dimerization and Super-complex Formation”, Z. Jia, M, O'Mara, J. Zuegg, M.A. Cooper, A. Mark, FEBS, 2013, 280 (5)1294-30.

“Aminoglycoside antibiotics in the 21st Century”, B. Becker, M.A. Cooper, ACS Chem Biol, 2013, 8 (1), 105-115. DOI: 10.1021/cb3005116

“Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumonia strains with under-acylated lipid A”, T. Velkov, R.L. Soon, P.L. Chong, J.X. Huang, M.A. Cooper, M.A.K. Azad, P.E. Thompson, K. Roberts, R.L. Nation, A. Clements, R.A. Strugnell & J. Li. Innate Immunity. 2013, 19(3): 265-77. doi: 10.1177/1753425912459092.

"The effect of environment on the recognition and binding of Vancomycin to native and resistant forms of Lipid II", Z-G Jia, M.L. O'Mara, J. Zuegg, M.A. Cooper & A.E. Mark. Biophys J.2013, 104(2): 516.



“Ligand-induced dimerization of the complement C5aR and C5L2 receptors by C5a but not C5a-des Arg”, D.D. Croker, R. Halai, D.P. Fairlie and M.A. Cooper, 2012, Immunobiol., 217(11), 1181-1182.

"Variation of the net charge, lipophilicity and side chain flexibility in Dmt1-DALDA: effect on opioid activity and biodistribution“ A. Novoa, S. Van Dorpe, E. Wynendaele, M. Spetea, N. Bracke, S. Stalmans, C. Betti, N. Chung, C. Lemieux, J. Zuegg, M. A. Cooper, D. Tourwé, B. De Spiegeleer, P. Schiller, S. Ballet, J. Med Chem, 2012, 55(22), 9549-61

“Tumour-suppressor gene promoter hypermethylation in saliva of head and neck cancer patients” D.A. Ovchinnikov, M.A. Cooper, P. Pandit, W.B. Coman, J.J. Cooper-White, P. Keith, E.J. Wolvetang, P.D. Slowey & C. Punyadeera, Transl Oncol., 2012, 5(5):321-6

“Lipoamino acids as major components of absorption promoters in drug delivery”, Z.M. Ziora, M.A. Blaskovich, I. Toth & M.A. Cooper. Curr Topics in Med Chem, 2012, 12(14):1562-80.

“Drug-Likeness and increased hydrophobicity of commercially available compound libraries for drug screening”, J. Zuegg & M.A. Cooper. Curr Topics Med Chem, 2012, 12(14), 1500-13.

“Drug-binding energetics of human α-1-acid glycoprotein assessed by isothermal titration calorimetry”, T. Velkov, M.A.K. Azad, J.X. Huang, M.A. Cooper, N. M. Ching, R.L. Nation & J. Li. J. Mol. Recognit. 2012, 25(12), 642-56.

“Identification of anti-tubercular benzothiazinone compounds by ligand-based design”, T. Karoli, B.Becker, J. Zuegg, U. Mollmann, S. Ramu, J.X. Huang & M.A. Cooper, J Med Chem, 2012, 55(17):7940-4.

“Resolving biofilm infections: Current therapy and drug discovery strategies”, M.V. Ranall, M.S. Butler, M.A. Blaskovich & M.A. Cooper. Curr. Drug Targets. 2012, 13(11), 1375-85.

“A survey of the 2010 Quartz Crystal Microbalance literature”, R.E. Speight & M.A. Cooper. J Mol. Recognit., 2012, 25(9):451-73.

“Molecular characterization of lipopolysaccharide binding to human α-1-acid glycoprotein”, J.X. Huang, M.A.K. Azad, R.L. Nation, J. Li, M.A. Cooper & T. Velkov. Journal of Lipids: Bacterial Lipids, 2012, 475153, doi: 10.115/2012/475153

“Development of anti-infectives using phase display: Biological agents against bacteria, viruses and parasites”, J.X. Huang, S.L. Bishop-Hurley, M.A. Cooper, Antimicrob Agents Ch, 2012, 56(9), 4569-82.

“A comparative study of impedance versus optical label-free systems relative to labelled assays in a predominantly Gi coupled GPCR (C5aR) signalling”, R. Halai, D. Croker, J.Y. Suen, D.P. Fairlie & M.A. Cooper, Biosensors, 2012, 2, 273-290.

“Oligonucleotide and polymer functionalized nanoparticles for amplification-free detection of DNA”, D.A.C. Thomson, E.H-L. Tee, N.T.D. Tran, M.J. Monteiro & M.A. Cooper. Biomacromolecules. 2012, 13, 1981-1989

“Structure-activity relationships for the binding of polymyxin antibiotics with human a-1-acid glycoprotein”. M.A.K. Azad, J.X. Huang, M.A. Cooper, K.D. Roberts, P.E. Thompson, J. Li, R.L. Nation, T. Velkov. Molecular Pharmaceutics, 2012, 84(3), 278-91.

“Carriage of an ACME II Variant has contributed to MRSA ST239-like Strain Replacement in Liverpool Hospital, Sydney, Australia.” B. Espedido, J. Steen, T. Barbagiannakos, J. Mercer, D. Paterson, S. Grimmond, M.A. Cooper, I. Gosbell, S. vanHal & S. Jensen. Antimicrob Agents Ch. 2012, 56(6), 3380-3383.

“The changing face of screening and drug discovery, Screening Asia 2011 Singapore: Conference Report.” M.A. Cooper. Exp. Rev. Proteomics, 2012, 9(2), 123-124.

"Structure aided design of chimeric antibiotics”, T. Karoli, S.K. Mamidyala, J. Zuegg, S.R. Fry, E.H-L. Tee, T.A. Bradford, P.K. Madala, J.X. Huang, S. Ramu, M.S. Butler & M.A. Cooper, Bioorganic & Medicinal Chemistry Letters, 2012  22, 2428-2433.

“Measurement of Drug Lipophilicity and pKa Using Acoustics”, X. Li & M.A. Cooper, Anal Chem. 2012 84(6), 2609-2613.

"Using label-free screening technology to improve efficiency in drug discovery”, R. Halai & M.A. Cooper, Expert Opinion on Drug Discovery, 2012, 7 (2), 123-131.

“Screening strategies to identify new antibiotics” M. S. Butler and M. A. Cooper, Current Drug Targets, 2012, 13(3), 373-387

top of page



"Fix the antibiotic pipeline" M.A. Cooper & D.A. Shlaes, Nature, 7 April 2011 472, 32

“Fluorogenic pyrosequencing in microreactors”, J.A. Steen & M.A. Cooper, Nature Methods, 8 (7) July 2011, 548-549.

“Expression of proton-sensing G Protein-Coupled Receptor 68 (OGR1) is increased by TNF-Mediated Inflammatory Signalling” C. de Valliere, C. Hiller, S. Kellermeier, I. Vetter, M. Inserra, R.J. Lewis, M.A. Cooper, S. Vidal, K. Seuwen, C.A. Wagner, M. Fried, G.A. Kullak-Ublick, G. Rogler, J.J. Eloranta, British Journal of Clinical Pharmacology, 2011, 72, 35-38.

“The effect of environment on the recognition and binding of vancomycin to native and resistant forms of lipid II”,Z-G. Jia, M. O’Mara, J. Zuegg, M.A.Cooper & A. Mark, The Biophysical Journal, 2011, 101 (11), 2684-2692.

"Antibiotics in the clinical pipeline", M.S. Butler and M.A. Cooper, Journal of Antibiotics, 2011, 64, 413-425.

"The diagnostic sensitivity of dengue rapid test assays is significantly enhanced by using a combined antigen and antibody testing approach", S.R. Fry, M. Meyer, M.G. Semple, C.P. Simmons, S.D. Sekaran, J. X. Huang, C. McElnea, C-Y. Huang, A. Valks, P.R. Young and M.A. Cooper, PLoS NTD, 2011, 5 (6) 1-8

"Cyclizations using selenium chemistry for substituted 3-hydroxypiperidines and 3-hydryxopyrrolidines" M.A. Cooper and A. David Ward, Aust. J. Chem. 2011, 64, 1327-1338.

"Biomarkers in Chronic Kidney Disease: a Review" R.G. Fassett, S.K. Venuthurupalli, G.C. Gobe, J.S. Coombes, M.A. Cooper and W. Hoy, Am. J. Kidney International. 2011, 80, 806-821.

“Separation and detection of bacteria using rupture event scanning” M.A. Cooper, F. N. Dultsev, V.P. Ostanin, D. Klenerman, Analytica Chimica Acta 2011, 702,233-238.

“A survey of the 2006-2009 quartz crystal microbalance biosensor literature”, M.A. Cooper and B. Becker, Journal of Molecular Recognition, 2011, 24, 754-787. doi: 10.1022/jmr.1117

"Amplification free detection of herpes simplex virus DNA from cerebrospinal fluid" D.A.C. Thomson, K. Dimitrov and M.A. Cooper, Analyst, 2011, 136 (8), 1599

"Membrane binding and perturbation studies of the antimicrobial peptides caerin, citropin, maculatin", B.C.S. Chia, Y. Gong, J.H. Bowie, J. Zuegg and M.A. Cooper, Biopolymers: Peptide Science, 2011, 96(2), 147-157



“The synthesis of Essramycin and comparison of its antibacterial activity”, E. H-L. Tee, T. Karoli, S. Ramu, J.X. Huang, M.S. Butler and M. A. Cooper, Journal of Natural Products, 2010, 73 (11), 1940-1942.

“Positive frequency shifts observed upon adsorbing micron-sized solid objects to a quartz crystal microbalance from the liquid phase”, A. Pomorska, D. Shchukin, R. Hammond, M.A. Cooper, G. Grundmeier, D. Johannsmann, Anal. Chem., 2010, 82 (6), 2237-2242.

“A signal amplification for HSV type 1 viral DNA detection using nanoparticles and direct acoustic profiling”, Y. Uludag, R. Hammond, M.A. Cooper, J. Nanobiotechnol., 2010 8 (3), doi:10.1186/1477-3155-8-3.

“How to stress superbugs”, M.A. Cooper Australasian Sci., 2010 31 (2), 31-32.

“Vancomycin dimer formation between analogues of bacterial peptidoglycan surfaces probed by force spectroscopy”, M. Batchelor, D. Zhou, M.A. Cooper, C. Abell and T. Rayment Org. Biomol. Chem., 2010, 8, 1142-1148.



“Bio-functionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms” J. Trmcic-Cvitas, E. Hasan, M. Ramstedt, X. Li, M.A. Cooper, C. Abell W.T.S. Huck and J.E. Gautrot, Biomacromolecules, 2009, 10 (10), 2885-2894.

“Signal transduction profiling using label-free biosensors”, M.A.Cooper, J. Recept. Signal. Transduct., 2009, 29 (3-4), 224-233.

“Resonant Acoustic Profiling for Diagnostics” M.A. Cooper SENSOR 2009 Proceedings, 2009, Vol. 1, 23-28, ISBN 978-3-9810993-4-8.

“Quantitative detection of Staphylococcal enterotoxin B by Resonant Acoustic Profiling”, M. Natesan, M.A. Cooper, J.P. Tran, V.R. Rivera, and M.A. Poli, Anal. Chem., 2009, 81 (10), 3896-3902.


“Nanomechanical detection of antibiotic-mucopeptide binding in a model for superbug resistance”, J.W. Ndieyira, M. Watari, A.D. Barrera, D. Zhou, M. Vogtli, M. Batchelor, M.A. Cooper, T. Strunz, M.A. Horton, C. Abell, T. Rayment, G. Aeppli and R.A.McKendry, Nature Nanotechnol., 2008, 3 (11), 691-696.

“Resonant Acoustic Profiling for Biological Detection and Diagnostics” W. Chiu, C.J. Hammond, R. Hammond, L. Harding, E. Hawkins, X. Li, S. Moore, K. Sanders, A. Sleptsov, C. Zhou and M.A. Cooper, Proc. IEEE Intl. Freq. Control Symp., 2008, 350-355.

“A high sensitivity assay for the inflammatory market C-Reactive protein employing acoustic biosensing”, J.D. McBride and M.A. Cooper, J. Nanobiotechnol., 2008, 6 (5).

“Direct acoustic profiling of DNA hybridization using HSV viral sequences”, Y. Uludag, X. Li, H. Coleman, S. Efstathiou and M.A. Cooper, Analyst, 2008, 132, 52-57.

“Single step biocompatible coating for sulfhydryl coupling of receptors via
2-(pyridinyldithio)ethylcarbamoyl dextran”, X. Li, C. Abell, and M.A. Cooper, Colloid Interfac. Sci. B., 2008, 61, 113-117.


“A survey of the 2001 to 2005 quartz crystal microbalance biosensor literature: applications of acoustic physics to the analysis of biomolecular interactions”, M.A. Cooper and V.T. Singleton, J. Mol. Recognit., 2007, 20 (3), 154-184.

“Piezoelectric sensors based on molecular imprinted polymers for quantitative detection of low molecular weight analytes”, Y. Uludağ, S.A. Piletsky, A.P.F. Turner and M.A. Cooper, FEBS, 2007, 274, 5471-5480.

“Profiling of molecular interactions in real time using acoustic detection”, B. Godber, M. Frogley, M. Rehak, A. Sleptsov, K.S.J. Thompson, Y. Uludag, and M.A. Cooper, Biosens. Bioelectron., 2007, 22 (9-10), 2382-2386.


“Acoustic detection technology in the analysis of biomolecular interactions”, E. Hawkins, M.A. Cooper and I. Campbell, Innovat. Pharm. Technol., 2006, 21, 30-34.

“Non-optical screening platforms: the next wave in label-free screening?”, M.A. Cooper, Drug Discov. Today, 2006, 11 (23/24), 1068-1074.

“Quantification of small molecule-receptor affinities and kinetics by acoustic profiling”, X. Li, K.S.J. Thompson, B. Godber, and M.A. Cooper, Assay Drug Dev. Technol., 2006, 4 (5), 565-573.

“Current biosensor technologies in drug discovery”, M.A. Cooper, Drug Discov. World, 2006, 7 (3), 68-82.

“Real-time label-free acoustic technology for rapid detection of E. coli 0157:H7” L. Huang and M.A.Cooper, Clin. Chem, 2006, 52 (11), 2148-2151.

“Optical biosensors; where next and how soon?”, M.A. Cooper, Drug Discov. Today, 2006, 11 (23/24), 1061-1067.

top of page


“Profiling molecular interactions using label-free acoustic screening”, M.A. Cooper and C.Whalen, Drug Discov. Today: Technologies., 2005, 2 (3), 241-245.

“Direct quantification of analyte concentration by Resonant Acoustic Profiling™ (RAP™)”, B. Godber, K.S.J. Thompson, M. Rehak, Y. Uludag, S. Kelling, A. Sleptsov, M. Frogley, K. Wiehler, C. Whalen and M.A. Cooper, Clin. Chem, 2005, 51 (10), 1962-1972.


“The photodynamic therapy (PDT) anticancer activity of a range of porphyrin dimers and related compounds derived from hematoporphyrin”, C.J. Byrne, M.A. Cooper, P.A. Cowled, R.A.W. Johnstone, L. Mackenzie, L.V. Marshallsay, I.K. Morris, C.A. Muldoon, M.J.Raftery, S.S. Yin and A.D. Ward., Aust. J. Chem., 2004, 57, 1091-1102.

“A biophysical characterisation of factors controlling dimerisation and selectivity in the NF-қB and NFAT families”, M. de Lumley, D.J. Hart, M.A. Cooper, S. Symeonides and J.M. Blackburn, J. Mol. Biol, 2004, 339 (5), 1059-1075.

“Formation of dihydroxyselenides from allylic alcohols and their conversion to -hydroxy epoxides via substitution of a phenylselenonyl group.”, M.A. Cooper and A.D. Ward, Tetrahedron, 2004, 60 (36), 7963-7972.

“Advances in membrane receptor screening and analysis”, M.A. Cooper, J. Mol. Recognit., 2004, 17 (4), 286-315.

“A novel method of resistance for influenza against a channel-blocking anti-viral drug”, P. Astrahan, I. Kass, M.A. Cooper and I. T. Arkin, Proteins: Structure, Function, and Bioinformatics. 2004, 55 (2), 251-257.



“Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM)”, D.T. Hickman, T.H.S. Tan, J. Morral, P.M. King, M.A. Cooper and J. Micklefield, Org. Biomol. Chem. 2003, 1 (19), 3277-3292.

“Biosensor profiling of molecular interactions in pharmacology”, M.A. Cooper, Curr. Op. Pharmacology, 2003, 3, 557-562.

“Label-free screening of bio-molecular interactions”, M.A. Cooper, Anal. Bioanal. Chem., 2003, 377 (5), 834-842.

“Biosensing using rupture event scanning (REVS)”, M.A. Cooper, Meas. Sci. Technol., 2003, 14, 1888-1893.

“G-Quadruplex-Specific Peptide-Hemicyanine Ligands by Partial Combinatorial Selection”, J.A. Schouten, S. Ladame, S.J. Mason, M.A. Cooper and S. Balasubramanian, J. Am. Chem. Soc., 2003, 125, 5594- 5595.

“Binding of an inhibitor of the p53/MDM2 interaction to MDM2”, S.J. Duncan, M A. Cooper and D.H. Williams, J. Chem. Soc. Chem. Commun., 2003, (3), 316-317.


“Sensitive and direct detection using Rupture Event Scanning (REVS)” S. Kelling, M.A. Cooper, K. Stirrups, R. Karamanska, V.P. Ostanin, D. Klenerman, A. Slepstov, M. Rehak, F.N. Dultsev, T. Minson and C. Abell, Proc. IEEE Intl. Freq. Control Symp., 2002, 756-760.

“Crystal structure of 2-(R*)-phenylselenomethyl-3(R*)-hydroxypyrrolidine-1-tosylate, C18H21NO3SSe”, M.A. Cooper, A.D. Ward and E.R.T. Tiekink, Z.Krist., 2002, 217, 343-344.

“Crystal structure of 2-(1-phenylselenonyl-1-phenylethoxy)ethanol, C16H18O4Se”, M.A. Cooper, A.D. Ward and E.R.T. Tiekink, Z.Kristallogr., 2002, 217, 345-346.

“A Sensitve and Economical Method to Directly Detect Particles”, M.A. Cooper, V.P. Ostanin, D. Klenerman, A. Slepstov, R. Karamanska, F.N. Dultsev, K. Stirrups, S. Kelling, T. Minson and C. Abell, Sensors 2002, Proceedings of IEEE, 2002, 2, 1042-1045.

“Optical Biosensors in Drug Discovery”, M.A. Cooper, Nature Rev. Drug Discov., 2002, 1, 515-528.

“Mechanism of the regulation of type IB phosphoinositide 3OH-kinase by G protein subunits”, S. Krugmann, M.A. Cooper, D.H. Williams, P.T. Hawkins, and L.R. Stephens, Biochem. J., 2002, 362 (3), 725-731.

"Label-free screening of molecular interactions using acoustic detection", M.A. Cooper, Drug Discovery Today, 2002, 7 (5), S5-S7.

"Acoustic detection of pathogens using rupture event scanning (REVS)", M.A. Cooper, Directions in Science, 2002, 1, 1-2.

"Identification of ARAP3, a Novel PI3K Effector Regulating Both Arf and Rho GTPases, by Selective Capture on Phosphoinositide Affinity Matrices", S. Krugmann, K.E. Anderson, S.H. Ridley, N. Risso, A. McGregor, J. Coadwell, K. Davidson, A. Eguinoa, C.D. Ellson, P. Lipp, M. Manifava, N. Ktistakis, G. Painter, J.W. Thuring, M.A. Cooper, Z.-Y. Lim, A.B. Holmes, S.K. Dove, R.H. Michell, A. Grewal, A. Nazarian, H. Erdjument-Bromage, P. Tempst, L.R. Stephens and P.T. Hawkins, Mol. Cell, 2002, 9 (1), 95-108.

"The orientation of the antibiotic peptide maculatin 1.1 in DMPG and DMPC lipid bilayers. Support for a pore-forming mechanism", C.S.B. Chia, J. Torres, M.A. Cooper, I.T. Arkin and J.H. Bowie, FEBS Lett., 2002, 512 (1-5), 47-51.


“Direct and sensitive detection of a human virus by rupture event scanning”, M.A. Cooper, F.N. Dultsev, T. Minson, V.P. Ostanin, C. Abell, and D. Klenerman, Nature Biotech., 2001, 19, 833-837.

"Phosphatidylinositol 3-phosphate regulates the neutrophil oxidase complex by binding to the PX domain of p40phox ", C.D. Ellson, S. Gobert-Gosse, K.E. Anderson, K. Davidson, H. Erdjument-Bromage, P. Tempst, J.W. Thuring, M.A. Cooper, Z.-Y. Lim, A.B. Holmes, P.R.J. Gaffney, J. Coadwell, E.R. Chilvers, P.T. Hawkins and L.R. Stephens, Nature Cell Biol., 2001, 3, 679-682.

"FENS-1 and FERG-1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments", S.H. Ridley, N. Ktistakis, K. Davidson, K.E. Anderson, M. Manifava, C.D. Ellson, P. Lipp, M. Bootman, J. Coadwell, A. Nazarian, H. Erjumont-Bromage, P. Tempst, M.A. Cooper, J.W.J.F. Thuring, z.-y. Lim, A.B. Holmes, L.R. Stephens and P.T. Hawkins, J. Cell. Sci, 2001, 114, 3991-4000.

"The synthesis of N-benzoyl aziridines from -benzamidoalkyl phenyl selenides", V.R. Ward, M.A. Cooper and A. D. Ward, Phophorus Sulfur Silicon and the Related Elements, 2001, 172 (1), 195-201.

"Kinetically selective binding of single stranded RNA over DNA by a pyrrolidine–amide oligonucleotide mimic (POM)", D.T. Hickman, P.M. King, J.M. Slater, M.A. Cooper, and J. Micklefield, Nucleosides, Nucleotides & Nucleic Acids, 2001, 20 (4), 1169-1172.

"Synthesis of N-acylaziridines from -amido selenides", V.R Ward, M.A. Cooper and A.D. Ward, J. Chem. Soc., Perkin Trans.I, 2001, 944-945.

“Chemical force microscopy with active enzymes”, M. Fiorini, R. McKendry, M.A. Cooper, T. Rayment, and C. Abell, Biophys J., 2001, 80, 2471-2476.

“A convenient method for the aromatic amino-Claisen rearrangement of N-(1,1-disubstituted-allyl)anilines”, M.A. Cooper, M.A. Lucas, J.M. Taylor, A.D. Ward and N.M. Williamson, Synthesis, 2001, 4, 621-625.


"Unusual RNA & DNA binding properties of a novel pyrrolidine–amide oligonucleotide mimic (POM)", D.T. Hickman, P.M. King, M.A. Cooper, J.M. Slater and J. Micklefield, J. Chem. Soc. Chem. Commun., 2000, 2251-2252.

“Binding of vancomycin group antibiotics to D-alanine and D-lactate presenting self-assembled monolayers”, M.A. Cooper, M.T. Fiorini, C. Abell, and D.H. Williams, Biorg. Med. Chem, 2000, 8, 2609-2616.

"The reactions of N-substituted-2-(2-dimethylallyl)aniline compounds with phenylselanyl halides", M.A. Cooper, C. L. Francis, J. W. Holman, B. Kasum, T. Taverner, E. R. T. Tiekink, and A. D. Ward, Aust. J. Chem, 2000, 53, 123-129.

"Kinetic analysis of high-mobility-group proteins HMG1 and HMGI/Y binding to cholesteroltagged DNA on a supported lipid monolayer", C.I. Webster, M.A. Cooper, L.C. Packman, D.H. Williams, and J.C. Gray, Nucleic Acids Res., 2000, 28 (7), 1618-1624.

"A vesicle capture sensor chip for kinetic analysis of binding to membrane-bound receptors ", M.A. Cooper, A. Hansson, S. Löfas, S. and D.H. Williams, Anal. Biochem., 2000, 277, 196-205.


"Binding of glycopeptide antibiotics to a model of a vancomycin-resistant bacterium", M.A. Cooper, and D. H. Williams, Chem. Biol., 1999, 6, 891-899.

"Kinetic analysis of an antibody-antigen interaction on a supported lipid monolayer", M.A. Cooper, and D.H. Williams, Anal. Biochem, 1999, 276, 36-47.

"High affinity surface binding of a strongly dimerising vancomycin group antibiotic to a model of resistant bacteria", D.P. O'Brien, R.M.H. Entress, M.A. Cooper, S.W. O'Brien, A. Hopkinson, and D.H. Williams, J. Am. Chem. Soc., 1999, 121, 5259-5265.

"Synthesis of extended bacterial cell-wall precursor analogues for ligand binding studies with glycopeptide antibiotics", T. Staroske, J. Görlitzer, R.M.H. Entress, M.A. Cooper and D.H. Williams, J. Chem. Soc., Perkin Trans. 1, 1999, 1105-1107.

"The salt dependence of DNA recognition by NF-[kappa]B p50: a detailed kinetic analysis of the effects on affinity and specificity", D.J. Hart, R.E. Speight, M.A. Cooper, J.D. Sutherland, J.M. Blackburn, Nucleic Acids Res., 1999, 27 (4), 1063-1069.


"Surface Plasmon Resonance Analysis at a Supported Lipid Monolayer", M.A. Cooper, A.C. Try, J. Carroll, D.J. Ellar, D.H. Williams, Biophys. Biochim, Acta, 1998, 1373, 101-111.

"Bacillus thuringiensis Cry1Ac toxin interaction with Manduca sexta aminopeptidase N in a model membrane environment", M.A. Cooper, J. Carroll, E.R. Travis, D.H. Williams and D.J. Ellar, Biochem. J., 1998, 333, 677-683.

"19F NMR in the measurement of binding affinities of chloroeremomycin to model bacterial cell-wall surfaces which mimic VanA and VanB resistance", R.M.H. Entress, R.J. Dancer, D.P. O'Brien, A.C. Try, M.A. Cooper and D.H. Williams, Chem. Biol., 1998, 5, 329-337.



"The roles of dimerisation and membrane anchoring in activity of glycopeptide antibiotics against vancomycin-resistant bacteria", G. J. Sharman, A.C. Try, R.J. Dancer, Y.R. Cho, T. Staroske, B. Bardsley, A.J. Maguire, M.A. Cooper, D.P. O'Brien and D.H. Williams, J. Am. Chem. Soc, 1997, 119, 12041-12047.

"Surface plasmon resonance analysis of glycopeptide antibiotic activity at a model membrane surface", M.A. Cooper, D.H. Williams, and Y.R. Cho, J. Chem. Soc. Chem. Commun., 1997, 17, 1625-1626.

“Synthesis and substitution reactions of N-protected-2-(phenylselenonylmethyl)-pyrrolidines”, M.A. Cooper and A. D. Ward, Aust. J. Chem., 1997, 50, 181-187.



"Crystal structure of ethyl 2-(phenylselenonylmethyl)pyrrolidine carboxylate", M.A. Cooper, E. R. T. Tiekink and A. D. Ward, Z.Krist., 1996, 211, 751-752.



"Hydroxyselenation of allylic alcohols", M.A. Cooper and A. D. Ward, Tetrahedron Lett., 1995, 36 (13), 2327-2330.

"Unusually stable hydrates of N-substituted 3-hydroxy-2 (phenylselenenyl)methylpiperidine derivatives. Where is the water? An NMR study", M.A. Cooper, S. M. Pyke, and A. D. Ward, Bull. Magn. Reson. 1995, 17 (1-4), 244-245.



"Selenium induced stereo-selective cyclization of N-substituted 4-hydroxy-5-hexenylamines", M.A. Cooper and A. D. Ward, Tetrahedron Lett., 1994, 35, 5065-5068.



"Selenium induced stereo-selective cyclizations of N-protected 3-hydroxy-4-pentenylamines", M.A. Cooper and A. D. Ward, Tetrahedron Lett., 1992, 33, 5999-6002.


10 patent families with 19 international filings.

top of page